Katie was getting nervous. At 16, she was the only one in her group offriends who had not started menstruating. Katie had always dreamedof having three beautiful children someday and she was worried. Hermother took her to see Dr. Josephine, who ordered several blood tests.When the results came back, Dr. Josephine gently explained to Katieand her mother that Katie would never be able to have children andwould never menstruate. Dr. Josephine then asked Katie to wait in theouter room while she spoke privately to her mother. She explained toKatie’s mom that Katie has androgen insensitivity syndrome. ThoughKatie is genetically male and her gonads produce more of the malereproductive hormone, testosterone, than the female reproductivehormone, estrogen, Katie did not reflect the tissue changes expected.What malfunction in Katie’s body would cause this? Why does Katie’sbody look feminine if she is genetically male?

Katie was getting nervous. At 16, she was the only one in her group of
friends who had not started menstruating. Katie had always dreamed
of having three beautiful children someday and she was worried. Her
mother took her to see Dr. Josephine, who ordered several blood tests.
When the results came back, Dr. Josephine gently explained to Katie
and her mother that Katie would never be able to have children and
would never menstruate. Dr. Josephine then asked Katie to wait in the
outer room while she spoke privately to her mother. She explained to
Katie’s mom that Katie has androgen insensitivity syndrome. Though
Katie is genetically male and her gonads produce more of the male
reproductive hormone, testosterone, than the female reproductive
hormone, estrogen, Katie did not reflect the tissue changes expected.
What malfunction in Katie’s body would cause this? Why does Katie’s
body look feminine if she is genetically male?

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