What is the function of cholinesterase in the synapse?  How does a cholinesterase inhibitor work in a synapse?  Explain how cholinesterase inhibitors are able to increase brain functioning and memory.

Alzheimer’s Disease 

Alzheimer’s disease is a progressive neurodegenerative disorder that affects almost 50 million people worldwide. The cause of Alzheimer’s disease is still not well understood. It is thought to be a combination of genetics, lifestyle, and environmental causes. It is also difficult to diagnose Alzheimer’s disease during the initial stages of the disease as symptoms can be mistaken for normal ageing. Currently, there is no cure for the disease. Medication can help manage the symptoms but degeneration of brain tissue cannot be stopped or reversed. 

Currently, the medication that manages the symptoms of Alzheimer’s disease is a type of cholinesterase inhibitor. In other words, the medication inhibits the function of cholinesterase and helps in brain functioning and memory. 

  1. What is the function of cholinesterase in the synapse? 
  2. How does a cholinesterase inhibitor work in a synapse? 
  3. Explain how cholinesterase inhibitors are able to increase brain functioning and memory. 
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